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Article

Power of inclusion: Enhancing polygenic prediction with admixed individuals.

American journal of human genetics - 2 Nov 2023

Tanigawa Yosuke, Kellis Manolis

Abstract excerpt

Admixed individuals offer unique opportunities for addressing limited transferability in polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many complex traits. However, they are rarely considered in PGS training, given the challenges in representing ancestry-matched linkage-disequilibrium reference panels for admixed individuals. Here we present inclusive PGS (iPGS), which...

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PMID: 37890495
DOI: 10.1016/j.ajhg.2023.09.013
PMCID: PMC10645553

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