Article
MAP-PRS: Multi-Ancestry Portfolio-Based Polygenic Risk Scores
2025-10-15
Abstract excerpt
Polygenic Risk Scores (PRS) are emerging tools for predicting an individual’s genetic risk for complex diseases. However, their usefulness in clinical practice remains limited because most existing models are based on data from people of European ancestry, leading to reduced accuracy and stability in other populations. This imbalance restricts the equitable use of PRS in precision medicine. To overcome these limit...
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Identifiers and source
- Literature Corpus work
- 10612620-de03-5b47-9945-2a67fa03df4f
- DOI
- 10.1101/2025.10.15.682516