Article

Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes

2025-09-28

Abstract excerpt

<h4>Background</h4> Iron accumulation is a hallmark of sporadic and familial Parkinson’s disease (PD) and correlates with clinical motor symptom severity. The biochemical mechanisms driving iron dyshomeostasis in PD brain and whether these are early or late events in the neurodegenerative process remain unknown. Nigral iron levels in LRRK2-PD patients have been reported to be even higher than in idiopathic PD, an...

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Literature Corpus work: c627ec3d-8103-5d63-ae39-aaf46e3da4c7
DOI: 10.1101/2025.09.26.678370

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