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The <i>SNCA</i> A53T mutation sensitizes human neurons and microglia to ferroptosis

2025-10-14

Abstract excerpt

The major pathological hallmarks of sporadic and familial forms of Parkinson’s disease (PD) are the targeted and progressive loss of midbrain dopaminergic neurons (mDA), associated with systemic iron accumulation, α-synuclein (αsyn) accumulation and aggregation, and lipid peroxidation amongst other reactive oxygen species (ROS) generation. Therapeutic strategies aimed towards dopamine restoration, αsyn removal and...

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Identifiers and source

Literature Corpus work
3e29b736-3ffd-54bd-9492-171b768f9b48
DOI
10.1101/2025.10.13.682089
Open publication

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