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Article

An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death.

Journal of cell science - 15 Jul 2026

Goldman Andres, Nguyen Mai, Lanoix Joël, Li Chongyang, Fahmy Ahmed, Xu Yong Zhong, Schurr Erwin, Thibault Pierre, Desjardins Michel, McBride Heidi M

Abstract excerpt

Altered iron homeostasis has long been implicated in Parkinson's disease (PD), although the mechanisms have not been clear. Given the critical role of PD-related activating variants in leucine-rich repeat protein kinase 2 (LRRK2) within membrane trafficking pathways, we examined the impact of the homozygous variant LRRK2G2019S on iron homeostasis within the RAW264.7 mouse macrophage cell line with high iron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42206576
DOI: 10.1242/jcs.264977
PMCID: PMC13490738

Genes

NCOA4
FTH1
RAB8A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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