Article

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson’s Tri-Culture Model

2025-08-02

Abstract excerpt

Astrocytes and microglia carrying the LRRK2-G2019S mutation contribute to non-cell- autonomous dopaminergic neuron (DAn) degeneration in Parkinson’s disease (PD), but the mechanisms underlying their interplay remain unclear. Here, we developed a novel induced pluripotent stem cell (iPSC)-derived tri-culture system comprising healthy DAn and either LRRK2-mutant or isogenic control iPSC-derived astrocytes and microg...

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Literature Corpus work: a3b3fb0d-43d7-5d91-8b94-d6e6c5a302a4
DOI: 10.1101/2025.08.01.668099

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