Article

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

2025-08-25

Abstract excerpt

Altered iron homeostasis has long been implicated in Parkinson’s Disease (PD), although the mechanisms have not been clear. Given the critical role of PD-related activating mutations in LRRK2 (leucine-rich repeat protein kinase 2) within membrane trafficking pathways we examined the impact of a homozygous mutant LRRK2G2019S on iron homeostasis within the RAW macrophage cell line with high iron capacity. Proteomics...

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Literature Corpus work: 894abee2-45ea-521d-b957-e89a178c7c82
DOI: 10.1101/2025.08.25.672135

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