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Iron Dysregulation in Parkinson’s Disease: Focused on the Autophagy–Lysosome Pathway

27 Dec 2018

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc). Although both iron accumulation and a defective autophagy-lysosome pathway contribute to the pathological development of PD, the connection between these two causes is poorly documented. The autophagy-lysosome pathway not only responds to...

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PMID: 30590010
DOI: 10.1021/acschemneuro.8b00390

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