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Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

19 Dec 2022

Abstract excerpt

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and contributes to neurodegeneration is poorly understood. Here we show that human induced pluripotent stem cell-derived microglia grown in a tri-culture system are highly...

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PMID: 36536241
DOI: 10.1038/s41593-022-01221-3

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