Article

The Parkinson’s disease associated Leucine-rich repeat kinase 2 affects expression of Transferrin receptor 1 and phosphorylation of key signaling proteins in human iPSC-derived dopaminergic neurons

2025-05-10

Abstract excerpt

Several variants in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene account for familiar and sporadic late-onset Parkinson’s disease (PD). LRRK2 is a large, multifunctional kinase involved in different intracellular pathways crucial for homeostasis and cell survival. One of the poorly understood mechanisms of Parkinsonism is the iron accumulation in Substantia nigra pars compacta ( SNc ). Transferrin receptor...

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Literature Corpus work: cbc307aa-c074-5339-a94b-41e0758a9d2a
DOI: 10.1101/2025.05.06.652393

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