Article

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

2021-11-02

Abstract excerpt

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS). One prominent feature of affected brain regions are iron-loaded microglia, but how iron overload influences microglia physiology and disease response is poorly understood. Here we show that microglia are highly susceptible to ferroptosi...

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Literature Corpus work: 02e10dd1-7ae5-5b04-8343-df140a7d1695
DOI: 10.1101/2021.11.02.466996

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