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Article

LRRK2 mutations: at the crossroads of dopamine, iron, and calcium imbalance in Parkinson's disease.

Acta neurobiologiae experimentalis - 24 Apr 2026

Skarżyńska Weronika, Moskal Aleksandra, Kuźnicki Jacek

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. The G2019S mutation in the leucine‑rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of familial and sporadic PD. In dopaminergic neurons, increased kinase activity caused by LRRK2‑G2019S mutation impairs synaptic vesicle recycling and dopamine storage, increasing cytosolic...

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PMID: 42370616
DOI: 10.55782/kre63y59

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