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Article

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

PLoS biology - 1 Dec 2021

Mamais Adamantios, Kluss Jillian H, Bonet-Ponce Luis, Landeck Natalie, Langston Rebekah G, Smith Nathan, Beilina Alexandra, Kaganovich Alice, Ghosh Manik C, Pellegrini Laura, Kumaran Ravindran, Papazoglou Ioannis, Heaton George R, Bandopadhyay Rina, Maio Nunziata, Kim Changyoun, LaVoie Matthew J, Gershlick David C, Cookson Mark R

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase Rab8a is a LRRK2 kinase substrate and is involved in receptor-mediated recycling and endocytic trafficking of transferrin, but the...

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Identifiers

PMID: 34914695
DOI: 10.1371/journal.pbio.3001480
PMCID: PMC8675653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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