Article

Efficient Methods for Target Gene Manipulation in Haematopoietic Stem Cell Derived Human Neutrophils

2023-06-18

Abstract excerpt

Neutrophils are the most abundant leukocyte in humans and the principal effectors of the innate immue response. Genetic modification of human neutrophils is challenging due to their short lifespan and tendency to activate in response to even minor perturbation. However, genetic manipulation of haematopoietic progenitor cells and subsequent directed differentation into neutrophils represents a potential avenue to s...

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Literature Corpus work: c5fe8e50-8c23-5556-ba18-fe7bb325a083
DOI: 10.1101/2023.06.17.545406

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