Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.

Abstract excerpt

Myeloid cells play critical and diverse roles in mammalian physiology, including tissue development and repair, innate defense against pathogens, and generation of adaptive immunity. As cells that show prolonged recruitment to sites of injury or pathology, myeloid cells represent therapeutic targets for a broad range of diseases. However, few approaches have been developed for gene editing of these cell types,...

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