Article

<i>GATA1</i> Knockout in Human Pluripotent Stem Cells Generates Enhanced Neutrophils to Investigate Extracellular Trap Formation

2023-04-28

Abstract excerpt

Human pluripotent stem cell (hPSC)-derived tissues can be used to model diseases and validate targets in cell types that are challenging to harvest and study at scale, such as neutrophils. Neutrophil dysregulation, specifically unbalanced neutrophil extracellular trap (NET) formation, plays a critical role in the prognosis and progression of multiple diseases, including COVID-19. hPSCs can provide a limitless supp...

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Literature Corpus work: d96749c7-28fc-55ec-8389-6b0667d4eb6e
DOI: 10.2139/ssrn.4430362

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