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Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

1 Jul 2022

Abstract excerpt

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer development and progression. Healthy primary neutrophils present potent cytotoxicity against various cancer cell lines through direct contact and via generation of reactive oxygen species. However, due to their short half-life and resistance to genetic modification, neutrophils have not yet been engineered with chimeric...

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PMID: 35858579
DOI: 10.1016/j.celrep.2022.111128

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