Article

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

2022-03-04

Abstract excerpt

<h4>SUMMARY</h4> Neutrophils, the most abundant white blood cells in the circulation, are closely related to cancer development and progression. Primary neutrophils from healthy donors present potent cytotoxicity against different human cancer cell lines through direct contact and via the generation of reactive oxygen species (ROS). However, due to their short half-life and resistance to genetic modification, neu...

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Literature Corpus work: 628db969-a073-54dd-bbe0-f6c66dff835c
DOI: 10.1101/2022.03.02.482679

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