Article
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2011
McDonald Jacqueline U, Cortini Andrea, Rosas Marcela, Fossati-Jimack Liliane, Ling Guang Sheng, Lewis Kimberley J, Dewitt Sharon, Liddiard Kate, Brown Gordon D, Jones Simon A, Hallett Maurice B, Botto Marina, Taylor Philip R
Abstract excerpt
Mature neutrophils are notoriously short-lived immune cells that cannot be genetically manipulated. Analysis of gene function therefore requires genetically modified animals, which is expensive, time-consuming, and costly in animal life. Analysis of gene function in neutrophils in a physiologically relevant context thus represents a significant problem in the field. We sought to overcome this obstruction in the...
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