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<i>GATA1</i> knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

2023-02-11

Abstract excerpt

Human pluripotent stem cell (hPSC)-derived tissues can be used to model diseases and validate targets in cell types that are challenging to harvest and study at-scale, such as neutrophils. Neutrophil dysregulation, specifically unbalanced neutrophil extracellular trap (NET) formation, plays a critical role in the prognosis and progression of multiple diseases, including COVID-19. hPSCs can provide a limitless supp...

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Literature Corpus work
33ee3330-b386-58fe-8845-72fcd98791c0
DOI
10.1101/2023.02.08.526339
Open publication

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<i>GATA1</i> knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formationDOI 10.1101/2023.02.08.526339
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