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Article

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable.

Journal of translational medicine - 31 May 2024

Naveh Claire A, Roberts Kiran, Zakrzewski Przemysław, Rice Christopher M, Ponce-Garcia Fernando M, Fleming Kathryn, Thompson Megan, Panyapiean Nawamin, Jiang Huan, Diezmann Stephanie, Moura Pedro L, Toye Ashley M, Amulic Borko

Abstract excerpt

BACKGROUND: Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to boost circulating neutrophil counts. Steady state and emergency granulopoiesis are incompletely understood, partly due to a lack of genetically amenable models of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38822352
DOI: 10.1186/s12967-024-05337-x
PMCID: PMC11143668

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