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Cas9 <sup>+</sup> conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function

2022-07-20

Abstract excerpt

Neutrophils are short-lived cells of the innate immune system that play numerous roles in defense against infection, regulation of immune responses, tissue damage and repair, autoimmunity, and other non-communicable diseases. Understanding neutrophil function at a mechanistic level has been hampered by the difficulty of working with primary neutrophils, which die rapidly upon isolation, and the relative paucity of...

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Identifiers and source

Literature Corpus work
7fce04cb-df63-52ce-b414-8e40dfeae825
DOI
10.1101/2022.07.19.500665
Open publication

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Cas9 <sup>+</sup> conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and functionDOI 10.1101/2022.07.19.500665
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