Article

Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core

2022-11-08

Abstract excerpt

<h4>ABSTRACT</h4> The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion. S2 is a class I fusion glycoprotein and contains a central coiled coil that acts as a scaffold for the conformational changes associated with fusion function. The coiled coil of S2...

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Literature Corpus work: c99b71d2-b734-5d7c-b3b0-8315965c9041
DOI: 10.1101/2022.11.08.515567

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