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Article

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.

Science advances - 1 Jan 2021

Xu Cong, Wang Yanxing, Liu Caixuan, Zhang Chao, Han Wenyu, Hong Xiaoyu, Wang Yifan, Hong Qin, Wang Shutian, Zhao Qiaoyu, Wang Yalei, Yang Yong, Chen Kaijian, Zheng Wei, Kong Liangliang, Wang Fangfang, Zuo Qinyu, Huang Zhong, Cong Yao

Abstract excerpt

The recent outbreaks of SARS-CoV-2 pose a global health emergency. The SARS-CoV-2 trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry into host cells. We report the cryo-EM structures of a tightly closed SARS-CoV-2 S trimer with packed fusion peptide and an ACE2-bound S trimer at 2.7- and 3.8-Å resolution, respectively. Accompanying ACE2 binding to the up receptor-binding...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33277323
DOI: 10.1126/sciadv.abe5575
PMCID: PMC7775788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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