Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation

22 Jul 2025

Abstract excerpt

The continued emergence of SARS-CoV-2 variants necessitates the development of immunogens that promote broad and durable immunity. The SARS-CoV-2 S2 fusion subunit drives viral entry and has sequence conservation among coronavirus spike proteins. Therefore, S2 could represent an immunogen to boost broadly reactive antibodies. However, when expressed without the S1 domain, metastable S2 irreversibly collapses into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40705599
DOI: 10.1016/j.celrep.2025.116052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationPMID 40705599Read ↗

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read ↗

Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike Variants.Semantic proximity Read ↗

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronavirusesSemantic proximity Read ↗

The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 PandemicSemantic proximity Read ↗

Stabilizing the Closed SARS-CoV-2 Spike TrimerSemantic proximity Read ↗

Structural Insights into the SARS-CoV-2 Spike Protein and Its Implications for Antibody Resistance.Semantic proximity Read ↗

Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronavirusesSemantic proximity Read ↗

Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity Read ↗

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopesSemantic proximity Read ↗

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variantSemantic proximity Read ↗

What makes SARS‐CoV‐2 unique? Focusing on the spike proteinSemantic proximity Read ↗

The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.