Article

Structural impact on SARS-CoV-2 spike protein by D614G substitution

2020-10-13

Abstract excerpt

Substitution for aspartic acid by glycine at position 614 in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing pandemic, appears to facilitate rapid viral spread. The G614 variant has now replaced the D614-carrying virus as the dominant circulating strain. We report here cryo-EM structures of a full-length S trimer carrying G614, which adopts...

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Literature Corpus work: fcc80245-72aa-57af-803b-f93192f94388
DOI: 10.1101/2020.10.13.337980

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