Article

A thermostable, closed, SARS-CoV-2 spike protein trimer

2020-06-17

Abstract excerpt

The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. S exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor binding site, and subsequently from prefusion to postfusion conformations to mediate fusion of viral and cellular membranes. S protein derivatives are components of vac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b41b3be-e461-5789-b134-1b06d77d6cf9
DOI: 10.1101/2020.06.15.152835

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A thermostable, closed, SARS-CoV-2 spike protein trimerDOI 10.1101/2020.06.15.152835Read

A thermostable, closed SARS-CoV-2 spike protein trimer.Semantic proximity Read

Stabilizing the Closed SARS-CoV-2 Spike TrimerSemantic proximity Read

Stabilizing the closed SARS-CoV-2 spike trimer.Semantic proximity Read

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.Semantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responsesSemantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensSemantic proximity Read

Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicitySemantic proximity Read

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.Semantic proximity Read

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variantSemantic proximity Read

SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicitySemantic proximity Read