Article
A thermostable, closed SARS-CoV-2 spike protein trimer.
Nature structural & molecular biology - 1 Oct 2020
Xiong Xiaoli, Qu Kun, Ciazynska Katarzyna A, Hosmillo Myra, Carter Andrew P, Ebrahimi Soraya, Ke Zunlong, Scheres Sjors H W, Bergamaschi Laura, Grice Guinevere L, Zhang Ying, Nathan James A, Baker Stephen, James Leo C, Baxendale Helen E, Goodfellow Ian, Doffinger Rainer, Briggs John A G
Abstract excerpt
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor-binding site and, subsequently, from prefusion to postfusion conformations to mediate fusion of viral and cellular membranes. S-protein derivatives are components of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.