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A synthetic stroma-free germinal center niche using material-surface driven polyvalent signaling efficiently induces antigen-specific humoral immunity <i>ex vivo</i>

2017-09-27

Abstract excerpt

B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal centers. Here, we report a fully synthetic ex-vivo system that recapitulates the generation of antig...

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Literature Corpus work
c53d9557-f2e3-5b1f-aae5-79774e5ca881
DOI
10.1101/194456
Open publication

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A synthetic stroma-free germinal center niche using material-surface driven polyvalent signaling efficiently induces antigen-specific humoral immunity <i>ex vivo</i>DOI 10.1101/194456
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