Article

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

2019-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic inflammation. A human model of LF formation would provide a tool to understand LF development and an alternative to non-human primate models for preclinical evaluation of vaccines. Here, we show that primary human blood B- and T-lymphocytes autonom...

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Literature Corpus work: 1d4f0c82-ff91-5817-864b-185ae922b873
DOI: 10.1101/806505

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