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Article

Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2014

Rookhuizen Derek C, DeFranco Anthony L

Abstract excerpt

Recent studies have demonstrated important roles of nucleic acid-sensing Toll-like receptors (TLRs) in promoting protective antibody responses against several viruses. To dissect how recognition of nucleic acids by TLRs enhances germinal center (GC) responses, mice selectively deleted for myeloid differentiation primary-response protein 88 (MyD88) in B cells or dendritic cells (DCs) were immunized with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25053813
DOI: 10.1073/pnas.1323985111
PMCID: PMC4128120

Genes

TLR9
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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