Article

Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen

2020-02-27

Abstract excerpt

<h4>SUMMARY</h4> Successful vaccines rely on activating a functional humoral response that results from generating class-switched high affinity immunoglobulins (Igs) with a superior capacity to neutralize infection. Key to this process is the germinal center (GC) reaction, in which B cells are selected in their search for antigen and T cell help. A major hurdle to understanding the mechanisms of B cell:T cell coo...

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Literature Corpus work: a020efe5-75ae-5a8b-a217-12f82ea06762
DOI: 10.1101/2020.02.26.965921

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