Article
Bioengineered human tonsil organoids as an immuno-engineering platform for evaluating immune functions
2025-10-06
Abstract excerpt
Although animal models remain the preclinical gold standard, they are constrained by interspecies differences in adaptive immunity, including antibody class-switching, affinity maturation, and multicellular interactions. To address this gap, we established a more physiologically relevant platform, a bioengineered tonsil organoid (BTO) system that combines autologous tonsil-derived stromal cells with immune cells t...
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Identifiers and source
- Literature Corpus work
- d587cdee-cb34-5902-abef-695b97026cd0
- DOI
- 10.1101/2025.10.04.680210