Article

Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells

2025-11-03

Abstract excerpt

<h4>Summary</h4> The engineering of autologous T cells to express chimeric antigen receptors (CARs) can induce profound clinical responses in haematological malignancies, while T cell receptor-engineered T (TCR T) cells have led to durable responses in clinical trials for solid tumours. However, clinical manufacturing of engineered T cells is resource-intensive and often yields highly differentiated, exhausted ef...

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Literature Corpus work: b58f4304-731c-525e-9713-e72ad799cb67
DOI: 10.1101/2025.11.01.686037

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