Article

DNA origami vaccines program antigen-focused germinal centers

2025-02-27

Abstract excerpt

Recruitment and expansion of rare precursor B cells in germinal centers (GCs) is a central goal of vaccination to generate broadly neutralizing antibodies (bnAbs) against challenging pathogens such as HIV. Multivalent immunogen display is a well-established method to enhance vaccine-induced B cell responses, typically accomplished by using natural or engineered protein scaffolds. However, these scaffolds themselve...

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Literature Corpus work: 61dad2cd-322f-55af-929b-f730a805511b
DOI: 10.1101/2025.02.21.639354

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