Article

A Multiscale Spatial Modeling Framework for the Germinal Center Response

2024-01-30

Abstract excerpt

The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymph organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells along with memory B cells. By interacting with follicular dendritic cells (FDC) and T follicular helper (Tfh) cells, GC B cells exhibit complex spatiotemporal dynamics. Dri...

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Literature Corpus work: 3530f233-b585-557f-96aa-d2ac6d05b194
DOI: 10.1101/2024.01.26.577491

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