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Article

Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production.

Nature protocols - 1 Jan 2017

Purwada Alberto, Singh Ankur

Abstract excerpt

Induction of B-cell immunity against infection depends on the initiation of the germinal center (GC) reaction in secondary lymphoid organs. Ex vivo recapitulation of the GC reaction in 2D cultures results in transient cell growth, with poor yield and short-term survival. Furthermore, no reported 2D ex vivo system can modulate the kinetics of a GC-like phenotype or the rate of antibody class switching. This...

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Identifiers

PMID: 28005068
DOI: 10.1038/nprot.2016.157
PMCID: PMC6355337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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