Article

Knockout of murine <i>Lyplal1</i> confers sex-specific protection against diet-induced obesity

2021-08-05

Abstract excerpt

Human genome-wide association studies found SNPs near LYPLAL1 that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects obesity and metabolic disease we created and characterized a mouse knockout of Lyplal1 . Here we show that CRISPR-Cas9 whole-body Lyplal1 knockout (KO) mice fed a high fat, high sucrose (HFHS) diet showed sex-specific differences in...

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Literature Corpus work: c52051ad-0630-5b9a-b50a-33c5f0ee96df
DOI: 10.1101/2021.08.05.455257

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