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Article

Lyplal1 is dispensable for normal fat deposition in mice.

Disease models & mechanisms - 19 Dec 2017

Watson Rachel A, Gates Amy S, Wynn Elizabeth H, Calvert Fiona E, Girousse Amandine, Lelliott Christopher J, Barroso Inês

Abstract excerpt

Genome-wide association studies (GWAS) have detected association between variants in or near the Lysophospholipase-like 1 (LYPLAL1) locus and metabolic traits, including central obesity, fatty liver and waist-to-hip ratio. LYPLAL1 is also known to be upregulated in the adipose tissue of obese patients. However, the physiological role of LYPLAL1 is not understood. To investigate the function of Lyplal1 in vivo we...

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Identifiers

PMID: 29084768
DOI: 10.1242/dmm.031864
PMCID: PMC5769613

Genes

LYPLAL1

Provenance

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