Article

Shift from visceral to subcutaneous fat in <i>Cyp17a1</i> knockout rats prevent the progression of metabolic syndrome

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> In this study, we investigated the effects of Cyp17a1 gene knockout (KO) on obesity and metabolic syndrome. Cyp17a1 KO in rats using CRISPR-Cas9 resulted in sex dimorphism and obesity, and interestingly, idiopathic accumulation was found in subcutaneous adipose tissue. Surprisingly, an insulin tolerance test and oral glucose tolerance test did not show any issues with insulin sensitivity and s...

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Identifiers and source

Literature Corpus work: 7bc65c75-7070-563b-a1ba-d3d28b06dc33
DOI: 10.1101/2024.09.22.614373

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