Article

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström Syndrome

2023-10-13

Abstract excerpt

<h4>Background</h4> Alström Syndrome (AS), a multi-system disease caused by mutations in the ALMS1 gene, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and hepatosteatosis. How loss of ALMS1 causes this phenotype is poorly understood, but prior studies have circumstancially implicated impaired adipose tissue expandability. We set out to test this by comparing the metabo...

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Literature Corpus work: 5da853cf-6fcc-57a7-9c89-1c23809888b7
DOI: 10.1101/2023.10.12.562074

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