Back to search

Article

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice

2023-02-03

Abstract excerpt

Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol (DAG), the penultimate step of triglyceride synthesis, which is essential for lipid storage. Herein we found that adipose tissue LPIN1 expression is decreased in peopl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b381e16e-a24d-5534-9c8f-3b78550fd18a
DOI
10.1101/2023.02.01.526676
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in miceDOI 10.1101/2023.02.01.526676
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.Semantic proximity
The lipin family: mutations and metabolism.Semantic proximity
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Semantic proximity
Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to HepatosteatosisSemantic proximity
Lipins: multifunctional lipid metabolism proteins.Semantic proximity
Comparative Transcriptomic Analysis of Obesity and Lipodystrophy Reveals Shared Mechanisms and Novel Targets in Adipose Tissue DysfunctionSemantic proximity
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in MiceSemantic proximity
Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.Semantic proximity
Adipose Tissue Inflammation, Oxidative Stress, and Altered Adipogenesis Are Drivers of Dyslipidemia – A Multi-Omics Overview of Dyslipidemia in ObesitySemantic proximity
Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities.Semantic proximity
Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.Semantic proximity
Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasisSemantic proximity
Select a neighboring publication to make it the new centre.