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The role of lipid metabolism in aging, lifespan regulation, and age‐related disease

27 Sept 2019

Abstract excerpt

An emerging body of data suggests that lipid metabolism has an important role to play in the aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid-related interventions extend lifespan in nematodes, fruit flies, mice, and rats. For example, the impairment of genes involved in ceramide and sphingolipid synthesis extends lifespan in both worms and flies. The overexpression of...

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PMID: 31560163
DOI: 10.1111/acel.13048

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