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Article

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Chella Krishnan Karthickeyan, Floyd Raquel R, Sabir Simon, Jayasekera Dulshan W, Leon-Mimila Paola V, Jones Anthony E, Cortez Angel A, Shravah Varun, Péterfy Miklós, Stiles Linsey, Canizales-Quinteros Samuel, Divakaruni Ajit S, Huertas-Vazquez Adriana, Lusis Aldons J

Abstract excerpt

BACKGROUND & AIMS: The etiology of nonalcoholic fatty liver disease (NAFLD) is poorly understood, with males and certain populations exhibiting markedly increased susceptibility. Using a systems genetics approach involving multi-omic analysis of ∼100 diverse inbred strains of mice, we recently identified several candidate genes driving NAFLD. We investigated the role of one of these, liver pyruvate kinase (L-PK...

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Source

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Identifiers

PMID: 32942044
DOI: 10.1016/j.jcmgh.2020.09.004
PMCID: PMC7788245

Genes

PCSK9
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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