Article

<i>ALMS1</i> KO rat: a new model of metabolic syndrome with spontaneous hypertension

2024-09-24

Abstract excerpt

ALMS1 is a protein initially associated with Alström syndrome. This is a rare human disorder characterized by metabolic dysfunction, hypertension, obesity and hyperinsulinemia. In addition, ALMS1 gene was linked to hypertension status in a multipoint linkage population analysis. However, the mechanisms by which ALMS1 contributes to the development of obesity, insulin resistance and other metabolic disturbances ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c1baf46-bd4f-54be-a8f8-66a4008f3510
DOI: 10.1101/2024.09.22.614364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>ALMS1</i> KO rat: a new model of metabolic syndrome with spontaneous hypertensionDOI 10.1101/2024.09.22.614364Read

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström SyndromeSemantic proximity Read

Knockout of murine <i>Lyplal1</i> confers sex-specific protection against diet-induced obesitySemantic proximity Read

A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice.Semantic proximity Read

Alström syndrome: an ultra-rare monogenic disorder as a model for insulin resistance, type 2 diabetes mellitus and obesitySemantic proximity Read

Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome.Semantic proximity Read

Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.Semantic proximity Read

Molecular genetics of experimental hypertension and the metabolic syndrome: from gene pathways to new therapies.Semantic proximity Read

Lean ZSF1 Rats in Basic Research on Heart Failure with Preserved Ejection FractionSemantic proximity Read

Loss of <i>RREB1</i> reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytesSemantic proximity Read

Genomic knockout of <i>alms1</i> in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypesSemantic proximity Read

Maternal Hyperleptinemia Improves Offspring Insulin Sensitivity in Mice.Semantic proximity Read

Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X.Semantic proximity Read