Article

Exploring the PLD1-tau interaction in Frontotemporal Dementia

2026-02-13

Abstract excerpt

<h4>Summary</h4> Frontotemporal dementia (FTD), a leading cause of young-onset dementia, is characterized by progressive behavioral and cognitive decline associated with frontotemporal cortical atrophy. Nearly 40% of cases exhibit tauopathy, yet the molecular drivers of tau aggregation leading to synaptic dysfunction remain poorly understood. Here, we investigated whether Phospholipase D1 (PLD1, a lipid signaling...

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Literature Corpus work: c4fe78ff-dbfa-5540-90e1-26fdbb9d9fde
DOI: 10.64898/2026.02.12.705569

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