Article
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell - 17 Feb 2022
Tracy Tara E, Madero-Pérez Jesus, Swaney Danielle L, Chang Timothy S, Moritz Michelle, Konrad Csaba, Ward Michael E, Stevenson Erica, Hüttenhain Ruth, Kauwe Grant, Mercedes Maria, Sweetland-Martin Lauren, Chen Xu, Mok Sue-Ann, Wong Man Ying, Telpoukhovskaia Maria, Min Sang-Won, Wang Chao, Sohn Peter Dongmin, Martin Jordie, Zhou Yungui, Luo Wenjie, Trojanowski John Q, Lee Virginia M Y, Gong Shiaoching, Manfredi Giovanni, Coppola Giovanni, Krogan Nevan J, Geschwind Daniel H, Gan Li
Abstract excerpt
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass spectrometry (AP-MS) followed by proximity ligation assay (PLA) to characterize Tau interactomes modified by neuronal activity and mutations that cause frontotemporal dementia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.