Article

PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer’s Disease Pathogenesis

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of Phospholipase D1 (PLD1) has been implicated in the progression of neurodegenerative diseases, including Alzheimer’s Disease (AD). This study investigated PLD1 signaling in synaptic integrity and cognition during aging and in a late-onset AD mouse model, hypothesizing differential effects of PLD1 modulation on synaptic vulnerability. AAV2-mediated gene transfer was employed to ov...

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Literature Corpus work: ace77861-f15a-5767-843c-4c46e40dd78b
DOI: 10.64898/2025.12.08.692971

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