Article

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release

2019-05-23

Abstract excerpt

<h4>Background</h4> Post-translational modifications of tau modify its interaction with binding partners and cause tau mislocalisation and altered tau function in Alzheimer’s disease (AD). The AD risk gene BIN1, is a binding partner for tau, however the mechanism by which BIN1 influences tau function is not fully understood. We hypothesised that BIN1 modulates AD risk by causing damaging tau mis-sorting to the sy...

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Literature Corpus work: ad23d981-da84-5a9d-a1eb-e3bbb583bf75
DOI: 10.1101/646406

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