Article

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

2019-05-08

Abstract excerpt

Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 ( APOE 4), exacerbates synapse loss and synaptic accumulation of oligomeric amyloid beta in human AD brain. To begin to understand the molecular casca...

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Literature Corpus work: 0d065045-a601-566b-8d84-9a695dd51691
DOI: 10.1101/631556

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